中文名称: |
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英文名称: |
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产品品牌: |
Pllabs |
产品编号: |
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产品规格: |
0.1mg/0.2mg |
产品包装: |
一支包装(原装进口、进口分装) |
其他名称: |
multidrug resistance-associated protein2; ABC30; ABCC2; ATP binding cassette sub family C (CFTR/MRP) member 2; ATP binding cassette subfamily C member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; CMOAT; CMOAT1; cMRP; DJS; KIAA1010; MRP 2; Multidrug resistance associated protein 2. |
免 疫 原: |
KLH conjugated synthetic peptide derived from human MRP2 N-terminus |
背景介绍: |
multidrug resistance-associated protein 2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Belongs to the ABC transporter family. |
应用范围: |
hu, mo, rat(Please decide the specificity by homology) |
更多产品: |
www.pllabs.com(加拿大PLlabs公司官网) |
其他产品: |
www.otwobiotech.com(华拓生物中文网) |
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