IL-4 Antibody

Catalog Number:  PL030581R
      Quantity size:0.1ml (1mg/1ml. Reconstitute with 0.1ml sterile distilled water.)

Immunogen:       KLH conjugated synthetic peptide derived from mouse IL-4 C-terminus

Clonality:         Rabbit Polyclonal IgG

Purity:           affinity purified by Protein A

Form:            Lyophilized or Liquid

Storage Buffer:    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Background: Interleukin4 is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of natve CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10 and IL13, which tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Also known as:  B cell growth factor 1; B cell IgG differentiation factor; B Cell Stimulatory Factor 1; BCGF 1; BCGF1; Binetrakin; BSF 1; BSF1; HCGF; Hodgkin’s Cell Growth Factor; IA Inducing Factor; IGG1 induction factor; IL 4; Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2.

predicted molecular weight: 14kDa

Specificity Reaction:  Mouse, Rat,               

                  （Please decide the specificity by homology）

Application: · WB=1:100-500 · ELISA=1:500-1000 · IP=1:20-100 · IHC-P=1:100-500  · IHC-F=1:100-500 · IF=1:100-500· Optimal working dilutions must be determined by the end user.

Storage:     Store at -20°C for one year. Avoid repeated freeze/thaw cycles. The Lyophilized or Liquid antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4°C. 

important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.