Mavorixafor trihydrochloride (AMD-070 trihydrochloride) 是一种有效的，选择性的，可口服的 CXCR4 拮抗剂，能够拮抗 125I-SDF 与 CXCR4 结合，IC50 值为 13 nM；Mavorixafor trihydrochloride (AMD-070 trihydrochloride) 能够抑制 HIV-1 (NL4.3 strain) 的复制，在 MT-4 和 PBMCs 细胞中，IC50 值分别为 1 和 9 nM。
Molecular Weight
458.86
458.86
Formula
C₂₁H₃₀Cl₃N₅
C₂₁H₃₀Cl₃N₅
CAS No.
2309699-17-8
2309699-17-8
SMILES
[H]Cl.[H]Cl.[H]Cl.NCCCCN(CC1=NC2=CC=CC=C2N1)[C@@H]3C4=NC=CC=C4CCC3
[H]Cl.[H]Cl.[H]Cl.NCCCCN(CC1=NC2=CC=CC=C2N1)[C@@H]3C4=NC=CC=C4CCC3
参考文献
[1]. Skerlj RT, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53(8):3376-88.
[2]. Uchida D, et al. Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells. oncol Rep. 2018 Jul;40(1):303-308.
[1]. Skerlj RT, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53(8):3376-88.
[2]. Uchida D, et al. Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells. oncol Rep. 2018 Jul;40(1):303-308.
