华拓生物科技有限公司

中文名称：

 基质金属蛋白酶-1抗体

英文名称：

 Anti-MMP-1

产品编号：

 PL030424R

免 疫  原：

 KLH conjugated synthetic peptide derived from human MMP1 C-terminus

克隆类型：

 Rabbit Polyclonal IgG

产品规格：

 0.1mg/0.2mg

产品情况：

 一支包装

其他名称：

  CLGN; CLG; 27 kDa interstitial collagenase; Fibroblast collagenase; Interstitial collagenase; MMP1; MMP; 1Matrix metallopeptidase 1 (interstitial collagenase); Matrix metalloproteinase 1 (interstitial collagenase); Matrix metalloproteinase 1.

背景介绍：

 The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.

交叉反应
       物       种：

 Human, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, G        

（Please decide the specificity by homology）